Antitumor compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546154, C07D21538, C07D215233

Patent

active

055718221

ABSTRACT:
A method of inhibiting tumor-cell growth in a mammalian subject, by administering a therapeutically effective amount of a selected 2-phenyl-4-quinolone compound. The selected compound shows unexpectely high activity against a variety of solid tumor cells.

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Kasahara, A., et al., "A new synthesis of 2-aryl-4-quinolones," Chemistry and Industry 4: 121 (1981).
Kuo, S-C., et al., "Synthesis and Cytotoxicity of 1,6,7,8-Substituted 2-(4'-Substituted phenyl)-4-quinolones and Related Compounds: Identification as Antimitotic Agents Interacting with Tubulin," J. Med. Chem. 36: 1146-1156 (1993).
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Venturella, P., et al, "Synthesis of 1-methyl-2-phenyl-5-hydroxy-4-quinolone and improved synthesis of edulein," Gazzetta Chimica Italiana 100(7): 678-681 (1970).

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