Antitumor composition for oral administration

Details Antitumor composition for oral administration Antitumor composition for oral administration

1995-12-12

1997-09-09

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

A61K 3170

Patent

active

056657110

ABSTRACT:
An antitumor composition for oral administration, comprising a 2'-deoxy-2'-methylidenecytidine compound of the formula ##STR1## wherein R is a hydrogen or a halogen, and R.sup.1 and R.sup.2 are the same or different and each is a hydrogen, a halogen or an alkyl having 1 to 4 carbon atoms, an acid addition salt thereof or a hydrate thereof, and a sucrose ester of fatty acid(s). The pharmaceutical composition of the present invention comprising a DMDC compound useful as an antitumor agent based on its remarkable degenerative action on solid tumor shows an improved oral absorption.

REFERENCES:
patent: 5183882 (1993-02-01), Sakata et al.
patent: 5412089 (1995-05-01), Sakata et al.
Patent Abstracts of Japan, 63258818 A, Oct. 26, 1988.
Patent Abstracts of Japan, 03240731 A, Oct. 28, 1991.
Patent Abstracts of Japan, 06340531 A, Dec. 13, 1994.

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