Antitumor composition comprising pyrimidine type nucleic acid de

Details Antitumor composition comprising pyrimidine type nucleic acid de Antitumor composition comprising pyrimidine type nucleic acid de

1986-05-07

1990-04-10

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 49, 514256, A61K 3170

Patent

active

049161210

ABSTRACT:
An antitumor agent comprising (i) at least one pyrimidine type nucleic acid derivative having the general formula (I): ##STR1## wherein X represents a fluorine atom or a trifluoromethyl group, R.sup.1 and R.sup.2 may be the same or different and represent a hydrogen atom or an acyl group, R.sup.3 represents a hydrogen atom or a hydroxyl group, and
(ii) at least one 1-[(2-hydroxyethoxy)methyl]uracil derivative having the general formula (II): ##STR2## wherein Y represents a hydrogen atom, a halogen atom, a methyl group, a benzyl group, a benzyloxybenzyl group, a vinyl group, a nitro group, or an amino group and R.sup.4 represents a hydrogen atom or an acyl group.

REFERENCES:
Chadwick et al, Cancer Research, vol. 32, 1972, pp. 1045-1056.
Cancer Research Supplement, No. 3, pp. 1-125, 1955.
Cancer Chemotherapy Reports, vol. 1, pp. 1-109, 1959.
Sirotnak et al, Cancer Research, vol. 38, pp. 345-353, 1978.
Johnson et al, Cancer Treatment Review, vol. 2, pp. 1-31, 1975.

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