Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1999-02-11
2000-09-19
Guzo, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4353201, 536 231, 536 245, C12Q 168, C07H 2104, C12N 1563
Patent
active
061210005
ABSTRACT:
Compounds and methods for modulating cell proliferation, preferably inhibiting the proliferation of tumor cells are described. Compounds that may be used to modulate cell proliferation include antisense oligonucleotides complementary to regions of the mammalian ribonucleotide reductase genes.
REFERENCES:
patent: 5023252 (1991-06-01), Hseih
patent: 5034506 (1991-07-01), Summerton et al.
patent: 5225347 (1993-07-01), Goldberg et al.
patent: 5580859 (1996-12-01), Felgner et al.
patent: 5719262 (1998-02-01), Buchardt et al.
patent: 5766855 (1998-06-01), Buchardt et al.
Agarwal, et al., (1995) Oncogene, 11:427-438.
Agrawal, (1996) "Antisense oligonucleotides: Towards clinical trials," TIBTECH, 14:376-387.
Akhter, et al., (1991) "Interactions of antisense DNA oligonucleotide analogs with phospholipid membranes (liposomes)," Nucleic Acids Res., 19:5551-5559.
Alessi, et al., (1995) Meth. Enzymol., 255:279-290.
Altschul, S.F., et al., (1990) "Basic local alignment search tool," J. Mol. Biol., 215:403-410.
Amara, et al., (1994) "Phorbol ester modulation of a novel cytoplasmic protein binding activity at the 3'-untranslated region of mammalian ribonucleotide reductase R2 mRNA and role in message stability," J. Biol. Chem., 269:6709-6715.
Amara, et al., (1995) "Defining a novel cis element in the 3'-untranslated region of mammalian ribonucleotide reductase component R2 mRNA: Role in transforming growth factor-.beta..sub.1 inducted mRNA stabilization," Nucleic Acids Res., 23:1461-1467.
Amara, et al., (1996) "Defining a novel cis-element in the 3'-untranslated region of mammalian ribonucleotide reductase component R2 mRNA: cis-trans interactions and message stability," J. Biol. Chem., 271:20126-20131.
Anazodo, et al., (1995) "Sequence-specific inhibition of gene expression by a novel antisense oligodeoxynucleotide phosphorothioate directed against a nonregulatory region of the human immunodeficiency virus type 1 genome," J. Virol., 69:1794-1801.
Anazodo, et al., (1996) "Relative levels of inhibition of p24 gene expression by different 20-mer antisense oligonucleotide sequences targeting nucleotides +1129 to +1268 of the HIV-1 gag genome: An analysis of mechanism," Biochem. Biophys. Res. Commun., 229:305-309.
Ashihara, et al., (1979) "Cell Synchronization," Methods Enzymol., 58:248-262.
Barker, R.H. Jr., et al., (1996) "Inhibition of plasmodium falciparum malaria using antisense oligodeoxynucleotides," Proc. Natl. Acad. Sci. USA, 93(1):514-518.
Blaess, (1997) "Gene Therapy for Cancer," Scientific American, 276(6):111-115.
Bjorklund, S., et al., (1990) "S-phase-specific expression of mammalian ribonucleotide reductase R1 and R2 subunit mRNAs," Biochemistry, 29(23):5452-5458.
Bjorklund, et al., (1993) "Structure and promoter characterization of the gene encoding the large subunit (R1 Protein) of mouse ribonucleotide reductase," Proc. Natl. Acad. Sci. USA, 90:11322-11326.
Blin, et al., (1976) "A general method of isolation of high molecular weight DNA from eukaryotes," Nucleic Acids Res., 3:2303-2308.
Blosmanis, et al., (1987) Cancer Res., 47:1273-1277.
Boven, et al., (1992) "Phase II preclinical drug screening in human tumor xenografts: A first European multicenter collaborative study," Cancer Res., 52:5940-5947.
Bradley, et al., (1986) Proc. Natl. Acad. Sci. USA, 83:5277-5281.
Branch, (1998) TIBS, 23:45-50.
Brower, et al. (1998) "All clear for HIV-targeting ribozyme in phase II," Nature Biotechnology, 162(2):123.
Calabretta, et al., (1996) "Antisense strategies in the treatment of leukemias," Semin. Oncol., 23:78.
Caras, (1985) "Cloned mouse ribonucleotide reductase subunit M1 cDNA reveals amino acid sequence homology with Escherichia coli and herpes virus ribonucleotide reductases," Biol Chem., 260:7015-7022.
Chadee, et al., (1995) J. Biol. Chem., 270:20098-20105.
Chakrabarti, D., et al., (1993) "Cloning and characterization of subunit genes of ribonucleotide reductase, a cell-cycle-regulated enzyme, from Plasmodium falciparum," Proc. Natl. Acad. Sci. USA, 90:12020-12024.
Chan, et al., (1993) Biochemistry, 32:12835-12840.
Chang, et al., (1978) "Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase," Nature, 275:617-624.
Chaudhuri, M.M., et al., (1992) "cDNA sequence of the small subunit of the hamster ribonucleotide reductase," Biochimica et Biophysica Acta, 1171:117-121.
Chen, et al., (1993) "Mammalian ribonucleotide reductase R1 mRNA stability under normal and phorbol ester stimulating conditions: Involvement of a cis-trans interaction at the 3'-untranslated region," EMBO J., 12:3977-3986.
Chen, et al., (1994). "Defining a novel ribonucleotide reductase R1 mRNA cis element that binds to an unique cytoplasmic trans-acting protein," Nucleic Acids Res., 22:4796-4797.
Choy, et al., (1988) "Molecular mechanisms of drug resistance involving ribonucleotide reductase: Hydroxyurea resistance in a series of clonally related mouse cell lines selected in the presence of increasing drug concentrations," Cancer Res., 48:2029-2035.
Choy, et al., (1989) Biochem. Biophys. Res. Commun., 162:1417-1424.
Cole, et al., (1992) Science, 258:1650-1654.
Cregg, J.M., et al., (1993) "Recent advances in the expression of foreign genes in pichia pastoris,"Bio/Technology, 11:905-910.
Crooke, (1995) "Progress in antisense therapeutics," Hematol. Pathol., 2:59-72.
Damen, et al., (1989) "Generation of metastatic variants in populations of mutator and amplificator mutants," J. Natl. Cancer Inst., 81:628-631.
Damen, et al., (1991) "Transformation and amplification of the K-fgf Protooncogene in NIH-3T3 cells, and induction of metastatic potential," Biochem. Biophys. Acta, 1097:103-110.
Davis, et al., (1994) "Purification, characterization, and localization of subunit interaction area of recombinant mouse ribonucleotide reductase R1 subunit," Biol. Chem., 269:23171-23176.
Devereux, J., et al., (1984) "A comprehensive set of sequence analysis programs for the VAX," Nucleic Acids Res., 12:387-395.
Eckstein, (1985) "Nucleoside phosphorothioates," Ann. Rev. Biochem., 54:367-402.
Edwards, et al., (1985) Mol. Cell. Biol., 5:3280-3288.
Egan, et al., (1987) "Expression of H-ras correlates with metastatic potential: Evidence for direct regulation of the metastatic phenotype in 10T1/2 and NIH 3T3 cells," Mol. Cell. Biol., 7:830-837.
Eriksson, et al., (1984) "Cell cycle-dependent regulation of mammalian ribonucleotide reductase: The S phase-correlated increase in subunit M2 is regulated by de novo protein synthesis," J. Biol. Chem., 259:11695-11700.
Fan, et al., (1996) "Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential," Proc. Natl. Acad. Sci. USA, 93:14036-14040.
Fan, et al., (1996) "A link between ferritin gene expression and ribonucleotide reductase R2 protein, as demonstrated by retroviral vector mediated stable expression of R2 cDNA," FEBS Lett., 382:145-148.
Fan, et al., (1997) "The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments," Proc. Natl. Acad. Sci. USA, 94:13181-13186.
Felgner, (1997) "Nonviral strategies for gene therapy," Scientific American, Jun., 1997, pp. 102-106.
Flintoff, (1989) "Methotrexate," in: R.S. Gupta (ed.), Drug Resistance in Mammalian Cells, (pp. 1-14) Boca Raton, Florida: CRC Press.
Flory, C.M., et al., (1996) "Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint," Proc. Natl. Acad. Sci. USA, 93:754-758.
Fujita, et al., (1980) "Relationship of chemotherapy on human cancer xenografts in nude mice to clinical response in donor patient," Journal of Surgical Oncology, 15:211-219.
Fujita, et al., (1982) "Application of nude mouse-human cancer xenograft systems for sensitivity test of anticancer drugs," Gan To Kagaku Ryoho, 9(4):606-615 (English abstract).
Fujita, et al., (1984) "Experimental chemotherapy of human gastrointestinal and breast cancers in nude mice and its correlation to clinical effect," Gan
Wright Jim A.
Young Aiping H.
Genesense Technologies Inc.
Guzo David
Wang Andrew
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