Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1998-02-13
1999-07-06
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
4352521, 435825, C12P 1716, C12N 120
Patent
active
059196718
ABSTRACT:
The present invention relates to the novel antitumor antibiotic designated BMS-199687 and to its preparation. The compound is obtained by culturing a new strain of Actinomadura ferruginea. BMS-199687 demonstrates antitumor activity in standard antitumor animal model systems.
REFERENCES:
G.A. Snow, et al, "Chemical and Biological Properties of Mycobactins Isolated From Various Mycobacteria," Biochem. J., 115, pp. 1031-1045 (1969).
I. Bursuker, et al, Production of Interferon-.gamma. by In Vivo Tumor-Sensitized T Cells: Association with Active Antitumor Immunity, Journal of Interferon Research, 10, pp. 1-11 (1990).
E. Borenfreund, et al, A Simple Quantitative Procedure Using Monolayer Cultures for Cytotoxicity Assays (HTD/NR-90), J. Tissue Culture Methods, 9, pp. 7-9 (1984).
W. C. Rose, "Evaluation of Madison 109 Lung Carcinoma as a Model for Screening Antitumor Drugs," Cancer Treatment Reports, 65, No. 3-4, pp. 299-312 (1981).
Bursuker Isia
Chang Li-Ping
Hugill Robert
Mamber Stephen W.
Tsunakawa Mitsuaki
Bristol--Myers Squibb Company
Lilling Herbert J.
Morse David M.
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