Antitumor antibacterial agents

Details Antitumor antibacterial agents Antitumor antibacterial agents

1980-03-06

1982-11-23

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112R, 424177, C07C10352, C07G 700, A61K 3700

Patent

active

043604587

ABSTRACT:
An antitumor antibacterial complex referred to as BBM-928 is described which is produced by microbiological fermentation under controlled conditions using a species of actinomycetes. The bioactive components of the complex have pronounced antitumor activity and are moderately to weakly active against gram-positive and acid fast bacteria but practically inactive against gram-negative bacteria and fungi. Based on median survival time, the component designated BBM-928A is substantially more active than mitomycin C by a factor of 10 to 300 fold against intraperitoneally implanted mouse tumors.

REFERENCES:
J. I. Shoji, et al., The Journal of Antibiotics, vol. 14, No. 6, 335-339.
A. Dell, et al., J.A.C.S. 97, (1975) 2497-2502.

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