Antitumor and immunosuppressive 4-carbamoyl imidazolium-5-olate

Details Antitumor and immunosuppressive 4-carbamoyl imidazolium-5-olate Antitumor and immunosuppressive 4-carbamoyl imidazolium-5-olate

1980-08-07

1982-08-24

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548337, 2602399, C07D23364, C07D23328, C07D23366, A61K 31415

Patent

active

043460968

ABSTRACT:
There are provided compounds of the formula: ##STR1## wherein R is an alkyl sulfonyl group or a benzenesulfonyl group which may be substituted with a lower alkyl group, a lower alkoxy group, a nitro group or a halogen atom, and a process producing them, useful as antitumor agents and immunosuppressants.

REFERENCES:
patent: 2373298 (1942-03-01), Dougherty et al.
patent: 4140788 (1979-02-01), Atsumi et al.
Mizuno, et al., Journal of Antibiotics, 27, 775 (1974).
Schipper, et al., J.A.C.S., 74, 350 (1952).
Sakaguchi, et al., Journal of Antibiotics, 28, 798 (1975).
Tsujino, et al., Proceedings IAMS, 3, 441 (1974).
Miller, et al., J.A.C.S., 74, 2892 (1952).
Sakaguchi, et al., Cancer Research, 35, 1643 (1975).
Sakaguchi, et al., Proceedings IAMS, 3, 539 (1976).

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