Antitumor and immunosuppressive 4-carbamoyl imidazolium-5-olate

Details Antitumor and immunosuppressive 4-carbamoyl imidazolium-5-olate Antitumor and immunosuppressive 4-carbamoyl imidazolium-5-olate

1980-08-05

1982-03-02

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424266, 424270, 424273R, 544405, 546278, 548105, 548110, 548201, 548214, 548336, 548337, A61K 31415, A61K 31495, C07D40912, C07D40512

Patent

active

043178251

ABSTRACT:
There are provided compounds of the formula: ##STR1## wherein R is a heteroaroyl group containing a nitrogen, sulfur or oxygen atom which may be substituted with a lower alkyl group, an aralkyl group, an acyl group or a halogen atom; or a cycloalkanoyl group which may be substituted with a lower alkyl group, a lower alkenyl group, a halogen atom, a halogeno-lower alkenyl group, a phenyl group, a halogenophenyl group, a lower alkoxyphenyl group, a lower alkylphenyl group, a formyl group, a hydroxy group, an amino group, a carboxyl group, an aminomethyl group or an oxo group, its non toxic salt and a process for producing them. These compounds are useful as antitumor agents and immunosuppressants.

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Sakaguchi, K., et al., Proc. 1st Int. Cong. IAMS, 3, 539-541 (1974).

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