Antitumor and immunosuppresive 4-carbamoyl imidazolium-5-olate d

Details Antitumor and immunosuppresive 4-carbamoyl imidazolium-5-olate d Antitumor and immunosuppresive 4-carbamoyl imidazolium-5-olate d

1980-11-12

1982-06-01

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548337, A61K 31415, C07D23390

Patent

active

043328067

ABSTRACT:
There are provided compounds of the formula: ##STR1## wherein R is an adamantoyl group substituted with a lower alkyl group, a lower alkoxy group, a hydroxy group, a lower alkanoyloxy group, an aroyloxy group, a halogen atom, an acetamido group, a nitro group, an azide group, a trifluoromethyl group or a phenyl group which may be substituted with a nitro group, a halogen atom, a lower alkyl group or a lower alkoxy group and a process producing them. These compounds are useful as antitumor agents and immunosuppressants.

REFERENCES:
Mizuno et al., Journal of Antibiotics, vol. 27, No. 10 (1974) pp. 775-782.
Miller et al., J.A.C.S., vol. 74 (1952) pp. 2892-2894.
Sakaguchi et al., Journal of Antibiotics, vol. 28 (1975) pp. 798-803.
Tsujino et al., Proceeding of the First International Congress of IAMS, vol. 3 (1974) pp. 441-443.
Schipper et al., J.A.C.S., vol. 74 (1952), pp. 350-353.
Sakaguchi et al., Cancer Research, vol. 35 (1975) pp. 1643-1648.
Sakaguchi et al., Proceedings of the First International Congress of IAMS, vol. 3 (1974) pp. 539-541.

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