Antitumor and antibacterial peptide and methods of use

Details Antitumor and antibacterial peptide and methods of use Antitumor and antibacterial peptide and methods of use

1994-08-08

1996-05-14

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 530317, A61K 3800, A61K 3802, C04K 500, C04K 700

Patent

active

055167551

ABSTRACT:
A novel peptide, polydiscamide A, has been isolated from a marine sponge. This compound, and its derivatives, are useful as antibacterial and antitumor agents.

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patent: 4737510 (1988-04-01), Rinehart, Jr.
patent: 4808590 (1989-02-01), Higa et al.
patent: 5336757 (1994-08-01), Gulavita et al.
Uemura et al., J. Am. Chem. Soc., vol. 107, pp. 4796-4798, 1985.
Faulkner, D. J. (1984) "Marine Natural Products: Metabolites of Marine Invertebrates" Natural Products Reports 1:551-598.
Faulkner, D. J. (1986) "Marine Natural Products" Natural Products Reports 3:1-33.
Faulkner, D. J. (1987) "Marine Natural Products" Natural Products Reports 4:539-576.
Uemura, Daisuke et al. (1985) "Norhalichondrin A: An Antitumor Polyeter Macrolide from a Marine Sponge" J. Am. Chem. Soc. 107:4796-4798.
Matsunaga, S. et al. (1984) "Bioactive Marine Metabolites VI Structure Elucidation of Discodermin A. An Antimicrobial Peptide from the Marine Sponge Discodermia kilensis" Tetrahedron Letters 25(45):5165-5168.
Matsunaga, S. et al. (1985) "Bioactive Marine Metabolites VII Structures of Discodermins B, C, and D, Antimicrobial Peptides from the Marine Sponge Discodermia kiiensis" Tetrahedron Letters 26(7):855-856.
Matsunaga, S. et al. (1985) "Bioactive Marine Metabolites, IV. Isolation and the amino acid composition of discodermin A, an antimicrobial peptide, from the marine sponge Discodermia kilensis" Journal of Natural Products 48(2):236-241.

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