Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2011-05-17
2011-05-17
Cordero Garcia, Marcela M (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C435S375000
Reexamination Certificate
active
07943568
ABSTRACT:
Compounds and methods useful for the treatment of cancer in subjects in need of such treatment. The compounds are metabolites of the compound FK228 which have been identified as possessing HDAC inhibitory activity and anticancer properties. Further provided are compounds and methods for inducing apoptosis in cancer cells. Further provided are compounds and methods for inhibiting HDAC in cancer cells.
REFERENCES:
patent: 6670326 (2003-12-01), Nagai et al.
patent: 7098186 (2006-08-01), Nagai et al.
patent: 7314862 (2008-01-01), Naoe et al.
Nishino et al. Cyclic Tetrapeptides Bearing a Sulfhydryl Group Potently Inhibit Histone Deacetylases. Organic Letters. 2003. vol. 5, No. 26, pp. 5079-5082.
Somech et al. Histone deacetylase inhibitors—a new tool to treat cancer. Cancer Treatment Reviews. 2004, vol. 30, pp. 461-472.
Furumai et al. FK228 (Depsipeptide) as a Natural Prodrug That Inhibits Class I Histone Deacetylases. Cancer Res. 2002, vol. 62, pp. 4916-4921.
Chan Kenneth K.
Xiao Jin
Calfee Halter & Griswold LLP
Cordero Garcia Marcela M
The Ohio State University Research Foundation
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