Antitumor agents

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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07470788

ABSTRACT:
The invention provides compounds of formula I:wherein Y is F, Cl or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.

REFERENCES:
patent: 4629493 (1986-12-01), Ura et al.
patent: 6867219 (2005-03-01), Horwitz et al.
patent: 7109341 (2006-09-01), Horwitz et al.
patent: 2007/0054938 (2007-03-01), Horwitz et al.
patent: WO-03/011832 (2003-02-01), None
patent: WO-2004/005260 (2004-01-01), None
patent: WO-2007/030780 (2007-03-01), None
patent: WO-2007030780 (2007-03-01), None
Corbett, T. H., “Preclinical Antitumor Efficacy of Analogs of XK469: Sodium-(2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy] Propionate”,Martinus Nijhoff Publishers, Investigational New Drugs, 16, 2, (1998),129-139.
“Invitation to Pay Additional Fees and Partial International Search Report for corresponding PCT Application No. PCT/US2006/035184”, (Mar. 22, 2007), 8 pgs.
Hazeldine, S. T., “Design, Synthesis, and Biological Evaluation of Analogues of the Antitumor Agent, 2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy} propionic Acid (XK469)”,Journal of Medicinal Chemistry, 44(11), (2001), 1758-1776.
“International Application No. PCT/US2006/035184 International Search Report and Written Opinion mailed Jul. 2, 2007”, 20 pgs.

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