Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1983-12-27
1987-02-24
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
4241951, A61K 3902, A61K 3578
Patent
active
046456678
ABSTRACT:
This invention relates to an antitumor agent comprising as a main ingredient a chemically purified cell walls of microorganisms belonging to genus Bificobacterium having physical integrity of cell wall structure thereof, obtained without being subjected to chemical and/or physical destruction of said cell wall during removal of intracellular substances of said cell, and a process for manufacturing the same, which comprises the steps of; (a) treating said cells with surfactants, (b) treating said cells with proteases, nucleases, organic solvents and dilute acid, to remove intracellular substances out of said cells without destruction thereof, and (c) separating a chemically purified cell walls having physical integrity of cell wall structure thereof.
REFERENCES:
Chem. Abst. 95:13097s, 1981.
Chem. Abst. 100:101626x, 1984.
Hashimoto Yoshiyuki
Kawashima Takuji
Kuboyama Morio
Saito Minoru
Sekine Kazunori
Goldberg Jerome D.
Morinaga Milk Industry Co. Ltd.
Rollins Jr. John W.
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