Antitumor agent

Details Antitumor agent Antitumor agent

2011-06-28

2011-06-28

Maier, Leigh C (Department: 1623)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C514S026000, C514S058000

Reexamination Certificate

active

07968116

ABSTRACT:
A sugar-cholestanol compound which can be readily synthesized and which exhibits a satisfactory antitumor activity. An anticancer agent containing, as an active ingredient, a cholestanol compound represented by the following formula (1):or a cyclodextrin inclusion complexation containing the compound. A method for treating cancer using this compound.

REFERENCES:
patent: 2006/0193903 (2006-08-01), Yazawa et al.
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patent: WO 2005/007172 (2005-01-01), None
Pitha, J. et al “Amorphous water-soluble derivatives of cyclodextrins . . . ” J. Pharm. Sci. (1985) vol. 74, No. 9, pp. 987-990.
STN abstract of Dong et al, CN 1393484 (2003).
Junichi Goto, et al., “Synthesis of Conjugated Cholesterol and Cholestanols”, Chem. Pharm. Bull., vol. 27, No. 8, pp. 1926-1931, 1979.
U.S. Appl. No. 12/553,355, filed Sep. 3, 2009, Yazawa, et al.

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