Antitumor agent

Details Antitumor agent Antitumor agent

1981-05-20

1985-06-04

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

514274, A61K 3748, A61K 3170, A61K 31505

Patent

active

045214069

ABSTRACT:
An antitumor agent comprising a combination of 5-fluorocytosine and cytosinedeaminase has been developed. As to the practical administration procedure of the agent, it is preferable to carry out in such a manner that 5-fluorocytosine is first administered in any portion of the body, and cytosinedeaminase is then administered into the topically suffered portion. The administered 5-fluorocytosine is transferred into the suffered portion, and the 5-fluorocytosine is affected with the action of cytosinedeaminase to convert the former compound into 5-fluorouracil, resulting in that the necrosis of the tumor tissue is caused.

REFERENCES:
Chemical Abstracts 91:69278t (1979).

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