Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1999-04-26
2000-08-22
Low, Christopher S. F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, 514822, 530324, 530350, 530829, 424529, 424532, A61K 3800, A61K 3816
Patent
active
06107280&
ABSTRACT:
Antithrombotic materials and methods are provided for the treatment of thrombotic disorders, in which therapeutically effective amounts of BPI protein products are administered.
REFERENCES:
patent: 5089274 (1992-02-01), Marra et al.
patent: 5171739 (1992-12-01), Scott et al.
patent: 5198541 (1993-03-01), Elsbach et al.
patent: 5234912 (1993-08-01), Marra et al.
patent: 5308834 (1994-05-01), Scott et al.
patent: 5334584 (1994-08-01), Scott et al.
patent: 5348942 (1994-09-01), Little, II et al.
patent: 5420019 (1995-05-01), Theofan et al.
patent: 5439807 (1995-08-01), Grinna
patent: 5447913 (1995-09-01), Ammons et al.
patent: 5466580 (1995-11-01), White et al.
patent: 5466581 (1995-11-01), White et al.
patent: 5488034 (1996-01-01), McGregor et al.
patent: 5494896 (1996-02-01), Hansbrough
patent: 5523288 (1996-06-01), Cohen et al.
patent: 5532216 (1996-07-01), Espevik et al.
patent: 5576292 (1996-11-01), Elsbach et al.
patent: 5578568 (1996-11-01), Ammons et al.
patent: 5578572 (1996-11-01), Horwitz et al.
patent: 5741779 (1998-04-01), White et al.
Carr et al., "Granulocyte lysosomal cationic protein alters fibrin assembly: A possible mechanism for granulocyte control of clot structure," J. Lab. Clin. Med., 107:199-203 (1986).
Carr et al., "Large Fibrin Fibers Enhance Urokinase-Induced Plasmin Digestion of Plasma Clots," 29th Ann. Meeting Am. Soc. Hematol., Blood, 70(Suppl. 1):400a (1987).
Carr et al., "Platelet Factor 4 Enhances Fibrin Fiber Polymerization," Thrombosis Research, 45:539-543 (1987).
Carr et al., "Effects of Poloxamer 188 on the Assembly, Structure and Dissolution of Fibrin Clots," Thrombosis and Haemostasis, 66(5):565-568 (1991).
Cecil's Textbook of Medicine, 17th Edition, W.B. Saunders Co., Pennsylvania, pp. 1053-1058 (1985).
Chapter 52, "Coagulation Disorders," Cecil's Essentials of Medicine, 3rd Edition, W.B. Saunders Co., Pennsylvania, pp. 408-416 (1983).
Elsbach and Weiss, in Inflammation: Basic Principles and Clinical Correlates, Gallin et al., Eds., Chapter 30, Raven Press, Ltd. (1992).
Elsbach et al., "Separation and Purification of a Potent Bactericidal/Permeability Increasing Protein and a Closely Associated Phospholipase A.sub.2 From Rabbit Polymorphonuclear Leukocytes," J. Biol. Chem., 254(21):11000-11009 (1979).
Fears, R., "Kinetic studies on the effect of heparin and fibrin on plasminogen activators," Biochem. J., 249:77-81 (1988).
Gazzano-Santoro et al., "High-Affinity Binding of the Bactericidal/Permeability-Increasing Protein and a Recombinant Amino-Terminal Fragment to the Lipid A Region of Lipopolysaccharide," Infect. Immun. 60(11):4754-4761 (1992).
Gray et al., "Cloning of the cDNA of a Human Neutrophil Bactericidal Protein," J. Biol. Chem., 264(16):9505-9509 (1989).
Heyderman et al., "Is there a circulating anticoagulant in meningococcal disease," Proc. Brit. Paediatric Association, p. 40 (Abstract G13) (Apr. 17, 1991).
Hogg and Jackson, "Fibrin monomer protects thrombin from inactivation by heparin-antithrombin III: Implications for heparin efficacy," Proc. Nat'l Acad. Sci., USA, 86:3619-3623 (1989).
Hogg and Jackson, "Formation of a Ternary Complex between Thrombin, Fibrin Monomer, and Heparin Influences the Action of Thrombin on Its Substrates," J. Biol. Chem., 265(1):248-255 (1990).
Hogg and Jackson, "Heparin Promotes the Binding of Thrombin to Fibrin Polymer," J. Biol. Chem., 265(1):241-247 (1990).
Klement et al., "The Effect of Thrombin Inhibitors on Tissue Plasminogen Activator Induced Thrombolysis in a Rat Model," Thrombosis & Haemostasis, 68:64-68 (1992).
Majerus et al., Chapter 54, "Anticoagulant, Thrombolytic and Antiplatelet Drugs," Goodman & Gilman, The Pharmacological Basis of Therapeutics, 9th Edition, McGraw-Hill, NY, pp. 1341-1358 (1996).
Nenci et al., "Fibrin clots obtained from plasma containing heparin show a higher sensitivity to t-PA-induced lysis," Blood Coagulation and Fibrinolysis, 3:279-285 (1992).
Odrljin et al., "Thrombin Cleavage Enhances Exposure of a Heparin Binding Domain in the N-Terminus of the Fibrin .beta. Chain," Blood, 88(6):2050-2061 (1996).
Ooi et al., "A 25-kDa NH.sub.2 -Terminal Fragment Carries All the Antibacterial Activities of the Human Neutrophil 60-kDa Bactericidal/Permeability-Increasing Protein," J. Biol. Chem., 262(31):14891-14894 (1987).
Ooi et al., "Endotoxin Neutralizing Properties of the 25 kD N-Terminal Fragment of the 55-60 kD Bactericidal/Permeability-Increasing Protein of Human Neutrophils," J. Exp. Med., 174:649-655 (1991).
Parise et al., "Effects of low molecular weight heparins on fibrin polymerization and clot sensitivity to t-PA-induced lysis," Blood Coagulation and Fibrinolysis, 4:721-727 (1993).
Retzinger et al., "Complexation with Heparin Prevents Adhesion between Fibrin-coated Surfaces," J. Biol. Chem., 267(34):24356-24362 (1992).
Suffredini et al., "Promotion and Subsequent Inhibition of Plasminogen Activation After Administration of Intravenous Endotoxin to Normal Subjects," New Engl. J. Med., 320(18):1165-1172 (1989).
von der Mohlen et al., "Inhibition of Endotoxin-Induced Activation of the Coagulation and Fibrinolytic Pathways Using a Recombinant Endotoxin-Binding Proetin (rBPI.sub.23)," Blood, 85(12):3437-3443 (1995).
Weiss et al., "Cellular and Subcellular Localization of the Bactericidal/Permeability-Increasing Protein of Neutrophils," Blood, 69(2):652-659 (1987).
Bode et al., "Combinations of thrombolytic agents in acute myocardial infarction," Zeitschnift for Kardiologie, vol. 82 (Suppl. 2) 125-128 (1993).
Olsson et al., "Early Intravenous Beta Blockade and Thrombolytics in Acute Myocardial Infarction," Amer. J. Cardiology, vol. 72, No. 19 156G-169G (1993).
Ammons William Steve
White Mark L.
Low Christopher S. F.
Mohamed Abdel A.
Xoma Corporation
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