Antithrombotic intraocular lens

Details Antithrombotic intraocular lens Antithrombotic intraocular lens

1995-06-07

1996-12-17

Brittingham, Debra S.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Eye prosthesis

Intraocular lens

A61F 216

Patent

active

055848826

ABSTRACT:
The antithrombotic intraocular lens of the present invention carries a fibrinolytic substance conjugatedly immobilized on its surface and, as such, lyses insoluble proteins such as fibrin deposited on the lens surface from the blood and exudate after implantation to fully retain its lens function. Furthermore, the present invention inhibits adhesion of the lens to the surrounding tissues and contributes to accelerated recovery after operation. The present invention further provides a simple method for immobilizing a fibrinolytic substance by conjugation on the surface of a variety of lens materials including silicones. Moreover, because the fibrinolytic substance is immobilized only to the surface of the lens material, the dynamic and optical properties of the intraocular lens are not adversely affected.

REFERENCES:
patent: 4720512 (1988-01-01), Hu et al.
patent: 5080924 (1992-01-01), Kamel et al.
patent: 5171267 (1992-12-01), Ratner et al.
Biomaterials, vol. 10, pp. 511-516 (Oct., 1989).

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