Antithrombotic ethers

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S270700

Reexamination Certificate

active

07615568

ABSTRACT:
This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor (I).

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patent: 6140351 (2000-10-01), Arnaiz et al.
patent: 6313122 (2001-11-01), Beight et al.
patent: 6313151 (2001-11-01), Beight et al.
patent: 6372759 (2002-04-01), Beight et al.
patent: 6417200 (2002-07-01), Beight et al.
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patent: 6635657 (2003-10-01), Beight et al.
patent: 6689780 (2004-02-01), Beight et al.
patent: 2004/0058959 (2004-03-01), Herron et al.
patent: 2004/0097491 (2004-05-01), Herron et al.
patent: 2004/0242581 (2004-12-01), Herron et al.
patent: WO 02/10154 (2002-02-01), None
patent: WO 02/064567 (2002-08-01), None
patent: WO 2005/049604 (2005-06-01), None
Zhu, et al.: “Factor Xa Inhibitors: Recent Advances in Anticoagulant Agents” Annual Reports in Medicinal Chemistry, (2000), 35, 83-102.

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