Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-04-30
2000-02-15
Huang, Evelyn Mei
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514212, 5142335, 514318, 514326, 514380, 514443, 540602, 544141, 546194, 546202, 548518, 548523, 548525, 548243, 549 58, A61K 3140, A61K 3138, C07D40914, C07D40912
Patent
active
060253827
ABSTRACT:
This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
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Jones, C., et al., "Antiestrogens. 2. Structure-Activity Studies in a Series of 3-Aroyl-2-arylbenzo [b] thiophene Derivatives Leading to [6-Hydroxy-2-(4-hydroxyphenyl) benzo [b] thien-3-yl] [4-[2-(1-piperidinyl) ethoxy] phenyl] methanone Hydrochloride (LY156758), a Remarkably Effective Estrogen Antagonist with Only Minimal Intrinsic Estrogencity," J. Med. Chem., 27 (8), 1057-1066, 1984.
Bastian Jolie Anne
Chirgadze Nickolay Yuri
Denney Michael Lyle
Fisher Matthew Joseph
Foglesong Robert James
Eli Lilly and Company
Huang Evelyn Mei
Jackson Thomas E.
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