Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-11-15
2010-02-23
Kosack, Joseph R (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S318000, C514S353000, C514S365000, C514S378000, C514S381000, C514S406000, C514S423000, C514S424000, C514S443000, C514S448000, C514S461000, C514S473000, C544S176000, C546S194000, C546S308000, C548S200000, C548S248000, C548S250000, C548S374100, C548S537000, C549S057000, C549S072000, C549S295000, C549S487000
Reexamination Certificate
active
07666866
ABSTRACT:
This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.
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Zhu, et al.: “Factor Xa Inhibitors: Recent Advances in Anticoagulant Agents” Annual Reports in Medicinal Chemistry, (2000), 35, 83-102.
Herron, David K. et al: “1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa” J.Med.Chem. 43(5), 859-872 (2000).
Wiley, M. R. et al: “Structure-based design of potent, amidine-derived inhibitors of factor Xa: evaluation of selectivity, anticoagulant activity, and antithrombotic activity.” J.Med.Chem 43(5), 883-899 (2000).
Franciskovich Jeffry Bernard
Herron David Kent
Klimkowski Valentine Joseph
Marquart Angela Lynn
Masters John Joseph
Eli Lilly and Company
Jackson Thomas E.
Kosack Joseph R
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