Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-01-11
1999-01-12
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530317, 530328, A61K 3800, A61K 3812, C07K 750, C07K 764
Patent
active
058589724
ABSTRACT:
The present invention provides antithrombotic agents useful for the management of cardiovascular disease. The agents of the subject invention are novel cyclic peptides encompassed by the following formula:
REFERENCES:
Gilon et al. Biopolymers, 31, 745-750, Feb. 1991.
Paborsky et al., "A Peptide Derived from a Tissue Factor Loop Region Functions as a Tissue Factor-Factor VIIa Antagonist." Biochemistry, 34:153298-15333 (1995).
Barker et al., "Cyclic RGD peptide analogues as antiplatelet antithrombotics." J. Med. Chem., 35:2040-2048 (1992).
Cheng et al., "Design and synthesis of novel cyclic RGD-containing peptides as highly potent and selective integrin .alpha..sub.IIIb .beta..sub.3 antagonists." J. Med. Chem., 37:1-8 (1994).
Tschopp et al., "Inhibition of coronary artery reocclusion after thrombolysis with an RGD-containing peptide with no significant effect on bleeding time." Coronary Artery Dis., 4:809-817 (1993).
Scarborough et al., "Design of potent and specific integrin antagonists: Peptide antagonists with high specificity for glycoprotein IIb-IIIa." J. Biol. Chem., 268:1066-1073 (1993).
Scarborough et al., "Characterization of the integrin specificities of disintegrins isolated from american pit viper venoms." J. Biol. Chem., 268:1058-1065 (1993).
Collen et al., "Antithrombotic effects and bleeding time prolongation with synthetic platelet GPIIb/IIIa inhibitors in animal models of platelet-mediated thrombosis." Thrombosis & Haemostasis, 71:95-102 (1994).
Sims et al., "Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex." J. Biol. Chem., 266(12):7345-7352 (1991).
Phillips et al., "The glycoprotein Iib-IIIa complex in platelets and nucleated cells." In: Platelet Activation, H. Yamazaki & J.F. Mustard, eds., Academic Press, Toronto, 57-70 (1987).
Pelletier et al., "The activation state of the integrin .alpha.IIb.beta.3 affects outside-in signals leading to cell spreading and focal adhesion kinase phosphorylation." J. Biol. Chem., 270(30):18133-18140 (1995).
Savage et al., "Modulation of platelet function through adhesion receptors: a dual role for glycoprotein IIb-IIIa(Integrin .alpha.IIb.beta.3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor." J. Biol. Chem., 267(16):11300-11306 (1992).
Grzesiak and Pierschbacher, "Shifts in the concentrations of magnesium and calcium in early porcine and rat wound fluids activate the cell migratory response." J. Clin. Invest., 95:227-233 (1995).
Kirchhofer et al., "Calcium as a potential physiological regulator of integrin-mediated cell adhesion." J. Biol. Chem., 266(7):4471-4477 (1991).
Mullen Daniel G.
Pierschbacher Michael D.
Borin Michael
La Jolla Cancer Research Foundation
Tsang Cecilia J.
LandOfFree
Antithrombotic agents and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antithrombotic agents and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antithrombotic agents and methods of use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1515937