Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1984-02-17
1985-08-06
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 21, 514822, A61K 31725, C08B 3710
Patent
active
045335494
ABSTRACT:
The object of the invention is to provide a new antithrombotic agent.
Coagulation of blood acts through a cascade of stages, the mechanisms and interaction of which have not been fully clarified. The present invention provides a derivative of heparin which can be administered orally, topically, or parenterally to antagonize the effect of factor Xa to a greater extent than commercial porcine heparin. In addition, the derivative has insignificant USP anticoagulant and platelet aggregating activities.
The heparin derivative according to the invention, has a molecular weight of from about 2,500 to about 4,000 daltons, gives a positive metachromatic test for sulfated polysaccharides. Preferably, when isolated as the sodium salt, the derivative contains by elemental analysis about 26.2% carbon, 4.33% hydrogen, 1.98% nitrogen, 7.1% sulfur, and 9.8% sodium, the molar ratio C:N:S:Na being about 10:1.5:2:4.
REFERENCES:
patent: 3766167 (1973-10-01), Lasker
patent: 4119774 (1978-10-01), Andersson et al.
patent: 4122250 (1978-10-01), Schmer
patent: 4175182 (1979-11-01), Schmer
patent: 4281108 (1981-07-01), Fussi
Lasker, Adv. Exp. Med. Biol., vol. 52, pp. 119-130, 1975.
Lasker, Federation Proceedings, vol. 36, pp. 92-97, 1977.
Andersson et al., Thrombosis Research, vol. 9, pp. 575-583, 1976.
Hook et al., FEBS Letters, vol. 66, pp. 90-93, 1976.
LandOfFree
Antithrombotic agent does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antithrombotic agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antithrombotic agent will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-511998