Antithrombotic 4,5 di-t-butyl-imidazole derivatives

Details Antithrombotic 4,5 di-t-butyl-imidazole derivatives Antithrombotic 4,5 di-t-butyl-imidazole derivatives

1985-09-10

1986-04-15

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514397, 514400, 548323, 548336, 548346, A61K 31415, C07D23364, C07D40510, C07D40904

Patent

active

045828440

ABSTRACT:
Imidazole derivatives of the formula ##STR1## wherein X is hydrogen or C.sub.1-4 -n-alkyl and Y is thienyl, optionally substituted by methyl or fluorine, or a group of the formula ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 independently are hydrogen, methyl, fluorine, hydroxy or methoxy, or two of R.sup.1, R.sup.2 and R.sup.3 on adjacent carbon atoms taken together are methylenedioxy or ethylenedioxy, or one of R.sup.1, R.sup.2 and R.sup.3 is mono- or di-(C.sub.1-4 -n-alkyl)-amino and the other two are hydrogen, and physiologically compatible or pharmaceutically acceptable acid addition salts thereof, are described. These compounds of formula I inhibit the aggregation of the blood platelets.

REFERENCES:
patent: 3279918 (1966-10-01), Cassiers et al.
patent: 3473901 (1969-10-01), Deubenneville et al.
patent: 3652581 (1972-03-01), Spaenig et al.
Chemical Abstracts, 75:123487v (1971) [Visser, G., et al., Acta Crystallogr., Sect. B, 1971, 27 (Pt. 9), 1802-11].
Derwent Abstract of German OLS No. 2132079, 1/11/73.
Derwent Abstract of German OLS No. 2262187, 6/20/74.
Chemical Abstracts, vol. 56, Subject Index, p. 91N.
Ijpac Report on Nomenclature, J. Am. Chem. Soc., 82, 5517 (1960).

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