Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1990-09-04
1994-01-11
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424 9464, 435 691, 435 692, 435 696, 514 2, 514 8, 530384, 530395, C07K 710, A61K 3702
Patent
active
052781445
ABSTRACT:
Analogs of Factor Xa (Factor Xai) which are inactive as proteases in the prothrombinase reaction are useful in treatment of diseases characterized by thrombosis. These antithrombotic agents can be conveniently prepared using recombinant techniques.
REFERENCES:
patent: 5120537 (1992-06-01), Esmon et al.
Hoover et al., Cell (1978) 14:423-428.
Etingin et al., Cell (1990) 61:657-662.
Davie, E. W., Haemostasis and Thrombosis, Second Edition, R. W. Colman et al., eds., (1987) J. B. Lippencott, Philadelphia, Pa., Chapter 16, pp. 242-267.
Furie et al., Cell (1988) 53:505-518.
Steinberg et al., Haemostasis and Thrombosis, Second Edition, R. W. Colman et al., eds., (1987) J. B. Lippencott, Philadelphia, Pa., Chapter 7, pp. 112-119.
Di Scipio et al., Biochemistry (1977) 16:5253-5260.
Nesheim et al., J. Biol. Chem. (1979) 254:10952-10962.
Nesheim et al., J. Biol. Chem. (1981) 256(13):6537-6540
Skogen et al., J. Biol. Chem. (1984) 259(4):2306-2310.
Krishnaswamy et al., J. Biol. Chem. (1988) 263(8):3823-3824.
Husten et al., J. Biol. Chem. (1987) 262(27):12953-12961.
Girard et al., Nature (1989) 338:518-520.
Girard et al., Science (1990) 248:1421-1424.
Donwiddie et al., J. Biol. Chem. (1989) 264:16694-16699.
Waxman et al., Science (1990) 248:593-596.
Bajaj et al., J. Biol. Chem. (1973) 248(22):7729-7741.
Colman et al., Haemostasis and Thrombosis, Second Edition, R. W. Colman et al., eds., (1987) J. B. Lippencott, Philadelphia, Pa., Section 1, Chapter 1, pp. 3-17.
Kaul et al., Gene (1986) 41:311-314.
COR Therapeutics Inc.
Lee Lester L.
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