Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-08-29
1997-10-21
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
536 235, 4351723, 4352523, 4352402, 4353201, 935 11, 935 24, 935 66, C12N 1500, C12N 1512, C12N 1563
Patent
active
056795424
ABSTRACT:
Platelet antiadhesives (PAA) which are useful as antithrombotics are obtainable from snake venoms which have been identified using an assay which measures the ability of the venom to inhibit ristocetin- or botrocetin-induced agglutination of platelets in the presence of von Willebrand Factor. The antiadhesives of the invention are 20-24 kd dimers of smaller peptides, or effective portions thereof. Antibodies to these antiadhesives are also prepared and are useful in assays for PAA and for screening expression libraries for PAA encoding DNA.
REFERENCES:
patent: 3819605 (1974-06-01), Holleman et al.
patent: 4350625 (1982-09-01), Abe
patent: 5066592 (1991-11-01), Huang et al.
patent: 5336667 (1994-08-01), Kirby et al.
Andrews, R.K. et al., "Purification of Botrocetin from Bothrops jararaca Venom. Analysis of the Botrocetin-Mediated Interaction between von Willebrand Factor and the Human Platelet Membrane Glycoprotein IB-IX Complex", Biochemistry 28:8317-8326 (1989).
el-Asmar et al., "Coagulant Component in Cerastes cerastes (Egyptian Sand Viper) Venom", Medline Abstract No. 87179104 (1986).
Atoda, H. et al., "The Primary Structure of Coagulation Factor IX/Factor X-binding Protein Isolated from the Venom of Trimeresurus flavoviridis", The Journal of Biological Chemistry 266(23) Aug. 13, 1991:14903-14911.
Verheij et al., "Correlation of Enzymatic Activity and Anticoagulant Properties of Phospholipase A.sub.2 ", Eur. J. Biochem. 112:25-32 (1980).
Soslau et al., "Cerastes cerastes (Egyptian Sand Viper) Venom Induced Platelet Aggregation as Compared to Other Agonists", Medline Abstract No. 88134252 (1988 Feb. 15).
Becker et al., "Effects of an Anitplatelet Glycoprotein Ib Antibody on Hemostatic Function in the Guinea Pig", Blood 74(2):690-694 (1989).
Bellinger et al., "Prevention of occlusive coronary artery thrombosis By a Murine Monoclonal Antibody to Porcine von Willebrand Factor", Proc. Natl. Acad. Sci. USA 84:8100-8104 (1987).
Cadroy et al., "Comparison of the Antihemostatic and Anti-Thrombotic Effects of Monoclonal Antibodies (MoA) Against von Willebrand-Factor (vWF) & Platelet (p) Glycoprotein IIb/IIIa (GPIIb/IIIa)", Circulation 80(4):Supplement II II-24 (Abstract 0093) (1989).
Coller et al., "Studies With A Murine Monoclonal Antibody That Abolishes Ristocetin-Induced Binding of von Willebrand Factor of Platelets: Additional Evidence in Support of GPIb as a Platelet Receptor for von Willebrand Factor", Blood 61(1):99-110 (1983).
Fressinaud et al., "von Willebrand Factor--Mediated Platelet Adhesion to Collagen Involves Platelet Membrane Glycoprotein IIb-IIIa As Well As Glycoprotein Ib", J. Lab. Clin. Med. 112:58-67 (1988).
Geratz et al., "Specific Inhibition of Platelet Agglutination and Aggregation by Amidino Compounds", Thrombos. Haemostas. 39:411 (1978).
Kirby, "Evans Blue: A Specific Inhibitor of Factor VIII-Induced Platelet Agglutination", Thrombos. Diathes. haemorrah. 34:770 (1975).
Phillips et al., "Aurin Tricarboxylic Acid: A Novel Inhibitor of the Association of von Willebrand Factor and Platelets", Blood 72(6):1898-1903 (1988).
Ruan et al., "Monoclonal Antibody to Human Platelet Glycoprotein I", British Journal of Haematology 49:511-519 (1981).
Stein et al., "Antithrombotic Therapy in Cardiac Disease", Circulation 80:1501-1513 (1989).
Strony et al., "Thrombosis: Platelets in Arterial Thrombosis", Circulation 80:II-23 (Abstract) (1989).
Vincente et al., "Identification of a Site in a .alpha. Chain of Platelet Glycoprotein Ib That Participates in von Willebrand Factor Binding", J. Biol. Chem. 265(1):274-280 (1990).
M.S. Dennis et al. Proc. Natl. Acad. Sci. 87:2471-2475 (Apr. 1989).
E. Daoud et al. Thrombosis Research 42:55-62 (1986).
COR Therapeutics Inc.
Prouty Rebecca
Wax Robert A.
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