Antithrombogenic synthetic elastomer and process of preparation

Details Antithrombogenic synthetic elastomer and process of preparation Antithrombogenic synthetic elastomer and process of preparation

1986-04-16

1987-08-18

Welsh, Maurice J.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From reactant having at least one -n=c=x group as well as...

528 76, C08G 1810

Patent

active

046878319

ABSTRACT:
Antithrombogenic synthetic elastomer having repeat units comprising portion I which is a soft segment unit containing a polyether and portion II which is a hard segment unit: ##STR1## R is a straight-chain or branched-chain alkylene group containing 2 to 4 carbon atoms, R' is amide a urethane, an urea, n ranges up to 180, m is an integer of 1 to 20, l is an integer of 1 to 10, said polymer having a microdomain structure composed of soft and hard segments, the domains of which have an average size of 10 to 20 nm, and a molecular weight of about 80,000 to about 500,000.
The polymer shows little adhesion of blood platelets thereto, little deformation of adhering blood platelets and an excellent antithrombogenic property. This polymer has excellent mechanical properties as an elastomer. This polymer is useful for artificial organs such as blood vessels, kidneys, hearts, and for functional biomaterials and devices such as absorbents for biological components, carriers for sustained release preparations, adhesive materials for living tissue, injectors, blood bags and catheters.

REFERENCES:
patent: 3188302 (1965-06-01), Lorenz
patent: 3926922 (1975-12-01), Banon et al.

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