Antithrombogenic devices containing polysiloxanes

Details Antithrombogenic devices containing polysiloxanes Antithrombogenic devices containing polysiloxanes

1988-03-16

1990-03-06

Kight, John

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

528 29, 623 1, A61K 3174, C08G 7704, A61M 3500

Patent

active

049064657

ABSTRACT:
A crosslinked polymer network comprising the reaction product of a polyethylene oxide and a polyglycidoxypropylsiloxane is described. These materials demonstrate low in vivo platelet retention as well as a low thrombogenicity. As such, they can provide antithrombogenic properties to blood contacting devices such as catheters, artificial hearts, ventricular grafts and cardiovascular suture.

REFERENCES:
patent: 4378435 (1983-03-01), Takagi et al.
patent: 4625010 (1986-11-01), Hahn et al.
patent: 4666745 (1987-05-01), Hahn et al.
patent: 4675361 (1987-06-01), Ward, Jr.
patent: 4684709 (1987-08-01), Ona et al.
patent: 4686137 (1987-08-01), Ward, Jr.
Pekala et al., Biomaterials 7:372-378 (1986).
R. W. Pekala, "Synthesis and Characterization of Polyether/Polysiloxane Networks for Blood-Interfacing Applications".
S. Hosaka et al., J. Appl. Polym. Sci., 23, 2089-2098 (1979).
R. W. Pekala et al., J. Colloid & Interface Sci., 101, 120-128, (1984).
R. W. Pekala et al., Biomaterials, 7, 372-378 (1986).
A. S. Hoffman, "Polymers in Medicine and Surgery", (Plenum Press, New York, 1974), 33-44.
R. W. Pekala et al., Biomaterials, 7, 379-385 (1986).
B. Kanner et al., Industrial and Engineering Chemistry Product Research and Development, 6(2), 88-92 (1967).
R. Langer, Chem. Eng. Commun., 6, 1-48 (1980).
S. Wisniewski et al., J. Membr. Sci., 6, 299-308 (1980).
J. M. Anderson et al., ACS Symposium Series, 31, 167-179 (1976).
M. P. Embrey et al., Brit. Med. J., 28, 901-902 (1980).
C. T. Reinhart et al., J. Membr. Sci., 18, 227-239 (1984).
B. K. Davis, Proc. Natl. Acad. Sci., USA, 71, 3120-3123 (1974).
Y. W. Chien, ACS Symposium Series, 33, 53-71 (1976).
T. J. Roseman et al., ACS Symposium Series, 33, 33-52 (1976).
S. Yolles, "Polymers in Medicine and Surgery", R. L. Kronenthal et al., eds. (Plenum Press, New York 1975), 245-261.

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