Antithrombin protein and DNA sequences from black fly

Details Antithrombin protein and DNA sequences from black fly Antithrombin protein and DNA sequences from black fly

1998-03-06

2000-06-20

Spector, Lorraine

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514822, 530324, 530384, 435 691, 435348, 536 231, 536 235, A61K 3816, C07K 1400

Patent

active

060778253

ABSTRACT:
The invention is drawn to anti-thrombin proteins from the salivary glands of the species, Simulium. Methods for recombinant production of the protein as well as biomedical uses are provided.

REFERENCES:
patent: 5196403 (1993-03-01), Maraganore et al.
patent: 5356875 (1994-10-01), Sarmientos et al.
patent: 5439820 (1995-08-01), Sarmientos et al.
patent: 5472942 (1995-12-01), Sawyer et al.
Jacobs, et al. "Isolation and Characterization of a Coagulation Factor Xa Inhibitor from Black Fly Salivary Glands", Thrombosis and Haemostasis, vol. 64, pp. 235-238 (1990).
Abebe, et al. "Anticoagulant Activity In Salivary Gland Extracts of Black Flies (Diptera: Simuliidae)", J. Med. Entomol. vol. 31(6), pp. 908-911(1994).
Abebe, et al. "Novel Anticoagulant from Salivary Glands of Simulium vittatum (Diptera: Simuliidae) Inhibits Activity of Coagulation Factor V", J. Med. Entomol.. vol. 33(1), pp. 173-176 (1996).
Abebe, et al. "Simulidin: a Black Fly (Simulium vittatum) Salivary Gland Protein With Anti-thrombin Activity", J. Inset Physiol. vol. 41(11), pp. 1001-1006 (1995).

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