Antithrombin-heparin complex and method for its production

Details Antithrombin-heparin complex and method for its production Antithrombin-heparin complex and method for its production

1982-03-12

1984-05-01

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated to proteinaceous toxin or fragment thereof

424101, A61Y 31725, A61Y 3514

Patent

active

044461267

ABSTRACT:
A complex of antithrombin and high activity heparin is provided for use as a potent anticoagulant for humans. The complex is prepared by reversibly immobilizing it on a lectin-containing, water-insoluble gel matrix and then removing it from the matrix.

REFERENCES:
Jordan et al, J. Biol. Chem. 254, 8, pp. 2902-2913, 4/25/79.
Rosenberg et al., Proc. Nat. Acad. Sci., (1978), 75:7, 3065-3069.
Rosenberg et al., BBRL (1979), 86:4, 1319-1324.

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