Antispastic use of triazolo-pyridazine derivatives

Details Antispastic use of triazolo-pyridazine derivatives Antispastic use of triazolo-pyridazine derivatives

1998-12-09

2000-04-04

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 31495, A61K 3150

Patent

active

060461969

ABSTRACT:
A class of substituted 7,8-ring fused 1,2,4-triazolo[4,3-b]pyridazine derivatives, as shown in Formula I possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and a substituted alkoxy moiety at the 6-position, are selective ligands for GABA.sub.A receptors, in particular having high affinity for the .alpha.2 and/or .alpha.3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of muscle spasm or spasticity, e.g. in paraplegic patients. ##STR1##

REFERENCES:
patent: 4112095 (1978-09-01), Allen, Jr. et al.
patent: 4117130 (1978-09-01), Allen, Jr. et al.
patent: 4230705 (1980-10-01), Allen, Jr. et al.
patent: 4260755 (1981-04-01), Moran et al.
patent: 4260756 (1981-04-01), Moran et al.
patent: 4654343 (1987-03-01), Albright et al.

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