Antiserotonins, their preparation and pharmaceutical composition

Details Antiserotonins, their preparation and pharmaceutical composition Antiserotonins, their preparation and pharmaceutical composition

1995-06-06

1996-10-08

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514 63, 514221, 5142265, 514252, 514307, 514321, 514338, 544 49, 544229, 544249, 544363, 544368, 546 14, 546148, 546198, 5462711, A61K 31495, A61K 3155, A61K 31445, C07D23970, C07D40104, C07F 702

Patent

active

055631444

ABSTRACT:
This invention relates to compounds having the formula R.sub.1 -(CH.sub.2).sub.n -Het wherein R.sub.1 is a residue having the formula (B), (C), (D); Het represents a radical phenyl-4 tetrahydro-1,2,3,6 pyridyl-1 whose phenyl cycle is optionally substituted by a halogen atom or an alkyl, alkoxy or hydroxy radical; a radical phenyl-4 piperazinyl-1 whose phenyl cycle is optionally substituted by a halogen atom or an alkyl, alkoxy or hydroxy radical; R.sub.3 is a hydrogen atom or a phenyl radical; R.sub.4 is a hydrogen or halogen atom or a residue Het; R.sub.5 is a carbonyl or sulfonyl radical; R.sub.6 is a radical Si(CH.sub.3).sub.2 or C(CH.sub.3).sub.2 ; n equals 1, 2, 3 or 4; excepting {[(phenyl-4 tetrahydro-1,2,3,6 pyridyl-1)-2 ethyl] amino}-3 benzisothiazol-1,2 dioxyde-1,1; their salts, their preparation and medicaments containing them.

REFERENCES:
patent: 4104387 (1978-08-01), Wade et al.
patent: 4132725 (1979-01-01), Barcza
Jean-Luc Malleron et al Journal of Medicinal Chemistry, vol. 34, No. 8, p. 2477 (1991).
Perregaard et al. J. Med. Chem. 1992, 35, 4813-4822.
Leysen et al, Molecular Pharmacology 21: 301-314.

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