Antisense restenosis composition and method

Details Antisense restenosis composition and method Antisense restenosis composition and method

2006-08-22

2006-08-22

Epps-Ford, Janet L. (Department: 1633)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S006120, C435S325000, C435S375000, C536S024500

Reexamination Certificate

active

07094765

ABSTRACT:
The present invention provides an improved method for reducing the risk or severity of restenosis following cardiac angioplasty. The method includes administering to a target vessel region, a morpholino antisense compound having uncharged phosphorus-containing backbone linkages, and spanning the start codon of a human c-myc mRNA. Also disclosed are novel antisense compounds and compositions, and a method for assaying the effectiveness of antisense delivery and uptake to a target vessel region.

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Kutryk, M. et al., “Local Intracoronary Administration of Antisense Oligonucleotide Against c-mycfor the Prevention of In-Stent Restenosis”,Journal of the American College of Cardiology39(2):281-287, 2002.
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