Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-02-22
1997-03-11
Crouch, Deborah
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
935 34, C07H 2104, C12N 1500
Patent
active
056102887
ABSTRACT:
Antisense polynucleotides to human transforming growth factor alpha (TGF-.alpha.) and the receptor for human epidermal growth factor (rEGF) are disclosed. Those polynucleotides are about 30 to about 50 bases in length and each hybridizes to about 10 to about 25 bases flanking the start codon for the gene encoding those proteins. Use of those antisense polynucleotides alone, together and mixed with an antibody combining site-containing molecule that binds to rEGF in treating human growth factor-sensitive cancerous tumors such as prostate tumors is also disclosed.
REFERENCES:
patent: 4740463 (1988-04-01), Weinberg et al.
patent: 4816561 (1989-03-01), Todaro
patent: 4863899 (1989-09-01), Todaro
patent: 4999421 (1991-03-01), Brunck et al.
patent: 5004810 (1991-04-01), Draper
patent: 5087617 (1992-02-01), Smith
patent: 5098890 (1992-03-01), Gewirtz et al.
patent: 5107065 (1992-04-01), Shewmaker et al.
patent: 5132408 (1992-07-01), Baird et al.
patent: 5135917 (1992-08-01), Burch
Narayanan et al. Onwgene 7:553-561 (1992).
Ullrich et al. Nature 309:418-425 (1984).
Tseng et al (1994) Cancer Gene Therapy 1, 65-71.
van der Krol et al (1988) Biotechniques 6, 958-976.
Hunts et al (1986) FEBS Let. 206, 319-322.
Baserga et al (1992) Ann. NY Acad. Sci 600, 64-69.
Neckers et al (1992) Ann. NY Acad. Sci. 600, 37-44.
Stedman's Medical Dictionary, 22nd ed., The Williams & Wilkins Co., Baltimore (1972) pp. 204, 205, 421, 468 and 1119.
Rubenstein et al., Clin. Physiol. Biochem., 9:47-50 (1992).
Aaronson et al., In: Molecular Foundations of Oncology, S. Broder (ed.), Williams and Wilkins, Baltimore, MD., pp. 27-39, 1991.
Todd et al, J. Dent. Res., 70:917-923 (1991).
Marshall et al., Science, 259:1564-1570 (1993).
Gutierrez et al., The Lancet,359:715-721 (1992).
Journal of Cellular Biology, Supplement 17E, 1993, Abstracts S022 (p. 191) and S027 (p. 192) and Arnold et al. (no page number).
Wilding, The Prostate, 15:1-12 (1989).
Crouch Deborah
Hekton Institute for Medical Research
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