Antisense oligonucleotides to p53

Details Antisense oligonucleotides to p53 Antisense oligonucleotides to p53

1994-10-21

1997-08-05

Chambers, Jasemine C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

935 34, 935 36, C07H 2104, C12N 1500

Patent

active

056544154

ABSTRACT:
Antisense oligonucleotides and composition of oligonucleotides are taught which inhibit the proliferation of cells without affecting cell viability. p53 antisense oligonucleotides are shown to inhibit the proliferation of tissue culture cells expressing this gene. Methods of treating a patient with such antisense oligonucleotides is described.

REFERENCES:
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Harlow et al (1985) Molec. Cell. Biol. 5, 1601-1610.
Tuck et al (1989) Molec. Cell Biol. 9, 2163-2172.
Zon (1988) Pharm. Res. 5, 539-549.
Sambrook et al (1989) Molecular Cloning, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 14.5 and 14.15.
James (1991) Antiviral Chem & Chemother. 2, 191-214.

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