Antisense oligonucleotides targeted to .beta.-1 adrenoceptor and

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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435 6, 435455, 435375, 536 231, 536 241, 536 245, C07H 2104, A61K 4800, C12Q 168

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active

060873434

ABSTRACT:
Oligonucleotides, and compositions thereof, are disclosed which can be administered to human and animal subjects to inhibit the expression of .beta.1-adrenoceptor to thereby control hypertension and cardiovascular disease for prolonged periods with single doses. Methods for treating humans and animals using oligonucleotides and compositions are also disclosed.

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