Antisense oligonucleotides specific for the muscarinic type 2 ac

Details Antisense oligonucleotides specific for the muscarinic type 2 ac Antisense oligonucleotides specific for the muscarinic type 2 ac

1996-11-15

1998-04-14

LeGuyader, John L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 6, 435 911, 4351723, 4353201, 435325, 435353, 536 231, 536 2431, 536 245, A61K 4800, C12Q 168

Patent

active

057391190

ABSTRACT:
Antisense oligonucleotides specific for the muscarinic type 2 acetylcholine receptor mRNA have been identified. Administration of these oligonucleotides to animals resulted in an increase in memory and learning. Methods for discovering other oligonucleotides with the same activity are taught, as are uses of the antisense molecules for treatment of human and animal diseases.

REFERENCES:
Gewirtz et al. PNAS 93:3161-3163 (1996).
Rojanasakul Adv. Drug Delivery Rev. 18(1996) 115-131.

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