Antisense oligonucleotides specific for STK-1 and method for inh

Details Antisense oligonucleotides specific for STK-1 and method for inh Antisense oligonucleotides specific for STK-1 and method for inh

1994-01-14

1997-04-08

Crouch, Deborah

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

536 245, 135 34, C12N 1500, C07H 2104

Patent

active

056187092

ABSTRACT:
Oligonucleotides are provided having a nucleotide sequence complementary to at least a portion of the mRNA transcript of the STK-1 gene. These "antisense" oligonucleotides are hybridizable to the STK-1 mRNA transcript. Such oligonucleotides are useful in treating neoplastic diseases characterized by activation of STK-1 gene expression. The oligonucleotides are also useful as bone marrow purging agents in the treatment of leukemia and metastasized neoplasms.

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