Antisense oligonucleotides of human regulatory subunit RI.sub..a

Details Antisense oligonucleotides of human regulatory subunit RI.sub..a Antisense oligonucleotides of human regulatory subunit RI.sub..a

1991-05-20

1993-12-21

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

536245, 514 44, 552544, A61K 3170, A61K 3722, C07H 2102, C07H 2104

Patent

active

052719413

ABSTRACT:
Antisense oligonucleotides of human regulatory subunit RI-alpha of cAMP-dependent protein kinases are disclosed along with pharmaceutical compositions containing these oligonucleotides as the active ingredients. These antisense oligonucleotides have been shown to inhibit the growth of several cancer cell lines including HL-60, human colon carcinoma LS-174T, neuroblastoma cells, breast cancer cells, and gastric carcinoma cells. In addition, these oligonucleotides can inhibit the growth of human colon carcinoma cells transplanted in athymic mice.

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