Antisense oligonucleotides inhibiting human bcl-2 gene expressio

Details Antisense oligonucleotides inhibiting human bcl-2 gene expressio Antisense oligonucleotides inhibiting human bcl-2 gene expressio

1994-03-24

1998-03-31

Ziska, Suzanne E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 245, C07H 2104

Patent

active

057340331

ABSTRACT:
The present invention provides novel antisense oligodeoxynucleotides which are useful in inhibiting lymphoma or leukemia cells. The subject oligodeoxynucleotides are complementary to a strategic site in the mRNA sense strand to the human bcl-2 gene. Such oligodeoxynucleotide are provided either in their native state or as a derivative such as the phosphorothioate. In the preferred embodiments, these antisense oligodeoxynucleotide straddle the predicted translation-initiation site of the mRNA coding strand, the splice donor region, the splice acceptor region of the mRNA coding strand, or the 5'-cap region for the human bcl-2 gene.

REFERENCES:
patent: 4806463 (1989-02-01), Goodchild
Strasser et al Cell 67: 889, 1991.
Reed et al Can. Res. 50: 6565, 1990.
Williams Cell 65: 1097, 1991.
Tsujimoto et al PNAS 83: 5214, 1986.
Reed et al Science 236: 1295, 1987.
Stein et al. NAR 16(8): 3209, 1988.
Negrini et al Cell 49: 455, 1987.
Stull et al Pharnaceu. Res 12(4): 465, 1995.
Miller et al. Ant Cancer Drug Design. 2: 117, 1987.
Asseline et al., Proc. Natl Acad. Sci. USA 81:3297-3301 (1984).
Aviv et al., Proc. Natl. Acad. Sci. USA, 69:1408-1412 (1972).
Bishop, "Cellular Oncogenes and Retroviruses", Science, 235:305-311 (1987).
Blake et al., Biochemistry 24:6132-6138 (1985).
Boutorin et al., FEBS Letters 172:43-46 (1984).
Chen and Sigman, Proc. Natl. Acad. Sci. USA 83:7147-7151 (1986).
Chu et al., Proc. Natl. Acad. Sci. 82:963-967 (1985).
Chomczynski et al., Analyt. Biochem., 162:156-159 (1987).
Croce et al., "Molecular Basis Of Human B and T Cell Neoplasia", in: Advance in Viral Oncology, 7:35-51, G. Klein (ed.), New York: Raven Press, 1987.
Halder et al., Nature (London), 342:195-197 (1989).
Holt et al., Mol. Cell Biol. 8:963-973 (1988).
Kern et al., J. Clin. Invest., 81:237-244 (1988).
Knorre et al., Biochemie 67:785-789 (1985).
Morvan et al., Nucl. Acids Res., 14:5019-5032 (1986).
Reed et al., J. Immunol., 134:314-319 (1985).
Reed et al., J. Immunol., 134:1631-1639 (1985).
Reed et al., Mol. Cell Biol., 5:3361-3366 (1985).
Van den Elsen et al., Nature 312:413-418 (1984).
Vlassov et al., Nucl. Acids Res. 14:4065-4076 (1986).
Webb et al., Nucl. Acids Res. 14:7661-7674 (1986).
Weiss et al., J. Immunol., 138:2169-2174 (1987).
Wickstrom et al., Proc. Natl. Acad. Sci. USA, 85:1028-1-32 (1988).
Zamecnik and Stephenson, Proc. Natl. Acad. Sci. USA, 75:280-284 (1978).
Zamecnik et al., Proc. Natl. Acad. Sci. USA, 83:4143-4146 (1986).
John C. Reed et al., "BCL2-mediated tumorigenicity of a human T-lymphoid cell line: Synergy with MYC and inhibition by BCL2 antisense", Proc Natl. Acad. Sci. USA, 87:3660-3664 (1990).

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