Antisense oligonucleotides having tumorigenicity-inhibiting acti

Details Antisense oligonucleotides having tumorigenicity-inhibiting acti Antisense oligonucleotides having tumorigenicity-inhibiting acti

1995-06-07

1999-07-06

Campell, Bruce R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 245, A61K 4800, C07H 2104

Patent

active

059197722

ABSTRACT:
The invention encompasses tumorigenicity-inhibitiig antisense oligonucleotide sequences complementary to mRNA or double-stranded DNA that encodes mammalian DNA methyl transferase. It further encompasses methods for inhibiting tumorigenicity and pharmaceutical composition comprising the tumorigenicity-inhibiting antisense nucleotide.

REFERENCES:
MacLeod (1993) Molecular Biology of the Cell 4 (Suppl.) 193A:1126.
Rouleau et al. J. Biol. Chem. (1992) 267:7368-7377.
Li et al. (1992) Cell 69:915-926.
Razin et al. (1984) Biochim. Biophys. Acta 782:331-342.
Szyf et al. (1992) J. Biol. Chem. 267:12831-12836.
Szyf et al. (1985) J. Biol. Chem. 260:8653-8656.
Szyf et al. (1991) J. Biol. Chem. 266:10027-10030.
Ohtani-Fukita et al. (1993) Oncogone 8:1063-1967.
Feinberg et al. (1988) Cancer Res. 48:1159-1161.
Goelz and Vogelstein (1985) Science 228:187-190.
Feinberg and Vogelstein (1983) Nature 301:89-92.
Agrawal (1992) Trends in Biotech 10:152.
Stephenson and Zamenick (1978) Proc. Natl. Acad. Sci. USA 75:285.
Leonetti et al. (1988) Gene 72:323.
Burch and Mahan (1991) J. Clin. Invest. 88:1190.
Jones and Buckley (1990) Adv. In Cancer Res. 54:1-23.
Yen et al. (1992) Nucl. Acids. Res. 9:2287-2291.
Szyf et al. (1989) Proc. Natl. Acad. Sci. USA 86:6853-6857.
Szyf et al. (1990) Mol. Endocrin 4:1144-1152.
Zakut-Houri et al. (1983) Nature 306:594-597.
Gura, Science, 270:575-577 (1995).
Rojanasakul, Advanced Drug Delivery Reviews, 18:115-131 (1996).
Bennett, Science, 271:434 (1996).
Miller et al., Parasitology Today, 10(3):92-97 (1994).
Wu-Pong, Pharmaceutical Technology, 18:102-114 (1994).
Stull et al., Pharmaceutical Research, 12(4):465-483 (1995).
Wagner, Nature, 372:333-335 (1994).
Weiss, Science News, 139:108-109 (1991).
Westerman et al., Biomed. Biochem. Acta., 48(1):85-93 (1989).
Stein, CA et al., Science, 261:1004-1012 (1993).
Milligan, JF et al., Journal of Medicinal Chemistry, 36(14):1923-1937 (1993).
Uhlmann, E et al., Chemical Reviews, 90(4):543-584 (1990).
Szyf, M et al., Journal of Biological Chemistry, 267(18):12831-12836 (1992).
Macleod, AR et al., Journal of Biological Chemistry, 270(14):8037-8043 (1995).
El-Diery, WS et al., Proc. Natl. Acad. Sci USA, 88:3470-3474 (1991).
Baylin, SB et al., Cancer Cells, 3(10):383-390 (1991).

Affiliated with

Also associated with

Rating

Antisense oligonucleotides having tumorigenicity-inhibiting acti does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antisense oligonucleotides having tumorigenicity-inhibiting acti, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antisense oligonucleotides having tumorigenicity-inhibiting acti will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-899107