Antisense oligonucleotides for IL-8 and IL-8 receptor

Details Antisense oligonucleotides for IL-8 and IL-8 receptor Antisense oligonucleotides for IL-8 and IL-8 receptor

1997-02-05

1998-12-15

LeGuyader, John L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 2431, 435 6, 435 911, 4351723, 435325, 435354, 435366, 435375, 514 44, C07H 2100, C07H 2104, C12Q 168, C12N 1585

Patent

active

058499032

ABSTRACT:
Oligonucleotides are provided which are effective in inhibiting the growth, metastasis and/or angiogenesis of tumors, including particularly melanoma and/or lung cancer. Methods are also provided for use of these oligonucleotides in the treatment of diseases.

REFERENCES:
Agrawal Antisense oligonucleotides: Towards Clinical Trials TibTech vol. 14:376-387, 1996.
Sten & Kreig "Problems in intepretation of Data Derived from in vitro and in vivo use of Antisense Oligondeoxynucleotides." antisense Research and Development. vol. 4:67:69, 1994.
Stull et al. "Antigene, Ribozyme and Aptamer Nucleic Acid Drugs: Progress and Prospects." Pharmaceutical Research vol. 12(4):465-483, 1995.

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