Antisense oligonucleotides directed to papillomavirus

Details Antisense oligonucleotides directed to papillomavirus Antisense oligonucleotides directed to papillomavirus

1994-11-04

1997-10-28

Crouch, Deborah

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

935 6, C07H 2104, C12N 1500

Patent

active

056819447

ABSTRACT:
Oligonucleotides are provided which are capable of antisense interaction with messenger RNA of papillomavirus. Such oligonucleotides or oligonucleotide analogs can be used for diagnostics and therapeutics as well as for research purposes. In accordance with preferred embodiments of this invention, oligonucleotides are provided which are hybridizable with selected messenger RNA from a human papillomavirus. The oligonucleotide is able to inhibit the function of the RNA, and accordingly is useful for therapy for infections by such papillomavirus. In accordance with a preferred embodiment, portions of the papillomavirus are targeted for antisense attack. Thus oligonucleotides are preferably provided which hybridize with the E2, E6 and E7 messenger RNAs.

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