Antisense oligonucleotides directed against human ICAM-I RNA

Details Antisense oligonucleotides directed against human ICAM-I RNA Antisense oligonucleotides directed against human ICAM-I RNA

1993-10-12

1996-12-03

Rories, Charles C. P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2431, 536 243, 536 2433, 435 6, C07H 2104, C07H 2102

Patent

active

055809693

ABSTRACT:
The present invention provides a method for the treatment of septic shock and inflammatory complications of shock. A process for selectively inhibiting the expression of the human ICAM-I mRNA transcript using at least one oligonucleotide which is complementary to at least a portion of the human ICAM-I mRNA is disclosed, as are oligonucleotides which are complementary to portions of the ICAM-I mRNA and compositions comprising the oligonucleotides.

REFERENCES:
patent: 5284931 (1994-02-01), Springer et al.
E. Uhlmann et al. Chemical Reviews, vol. 90, #4, (Jun. 1990) pp. 543-584.
B. Y. Tseng et al. Cancer Gene Therapy, vol. 1, #1 (Mar. 1994) pp. 65-71.
C. A. Stein et al. Science, vol. 261 (Aug. 20, 1993) pp. 1004-1012.
R. Weiss Science News, vol. 139 (Feb. 16, 1991) pp. 108-109.
B. Monia et al. JBC, vol. 267, #28 (Oct. 5, 1992) pp. 19954-19962.
P. Westermann et al. B. B. Acta, vol. 48, #1 ('89) pp. 85-93.
M-Y. Chiang et al. JBC, vol. 266, #27 (Sep. 25, 1991) pp. 18162-18171.
E. Wickstrom et al. (Abstract) The FASEB Journal, vol. 5, #5 (Mar. 15, 19 p. A1443.
D. Staunton et al. Cell, vol. 52 (Mar. 25, 1988) pp. 925-933.
C. A. Stein et al. Cancer Research, vol. 48 (May 15, 1988) pp. 2659-2668.
M. Rothenberg et al. JNCI, vol. 81, #20 (Oct. 18, 1989) pp. 1539-1544.
S. Sankar et al. Eur. J. Biochem., vol. 184 ('89) pp. 39-45.
S. L. Loke et al. Cur. Top. in Microbiol. & Immunol., vol. 141 ('88) pp. 282-289.
C. P. Leamon et al. PNAS, vol. 88, (Jul. 1991) pp. 5572-5576.
S. Strickland et al. Science, vol. 241 (Aug. 5, 1988) pp. 680-684.

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