Antisense oligonucleotides complementary to the primary transcri

Details Antisense oligonucleotides complementary to the primary transcri Antisense oligonucleotides complementary to the primary transcri

1997-05-20

1999-10-19

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 6, 435 911, 435325, 435366, 4353721, 435375, 435440, 536 231, 536 2431, 536 2433, 536 245, C12Q 168, C07H 2104

Patent

active

059688254

ABSTRACT:
The following description sets forth antisense (AS) oligonucleotides (ODNs) complementary to the primary transcript of the human c-fes protooncogene and their use to inactivate said transcript. All-trans retinoic acid (ATRA) is reported to be used as a differentiation inducer on cells pretreated with said AS-ODNs to induce apoptosis of leukemic blast cells.

REFERENCES:
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