Antisense oligonucleotides capable of inhibiting the...

Details Antisense oligonucleotides capable of inhibiting the... Antisense oligonucleotides capable of inhibiting the...

2007-10-31

2010-12-21

McGarry, Sean R (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S006120, C435S375000, C435S377000, C536S023100, C536S024100, C536S024500

Reexamination Certificate

active

07855184

ABSTRACT:
A pharmaceutical composition blocks angiogenesis and contains as an active agent at least one nucleotide sequence from nucleic acid molecule SEQ ID NO. 3, fragments thereof containing at least twelve contiguous nucleotides and derivatives thereof; and nucleic acid sequences containing at least twelve contiguous nucleotides of the nucleic acid molecule SEQ ID NO 30 and derivatives thereof.

REFERENCES:
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patent: 92/13083 (1992-08-01), None
patent: 96/35791 (1996-11-01), None
Consuelo D'Ambrosio et al.,Transforming Potential of the Insulin Receptor Substrate I1, Cell Growth & Differentiation, vol. 6, May 1995, pp. 557-562.
Ewa Surmacz et al.,Overexpression of Insulin Receptor Substrate 1(IRS-I)in the Human Breast Cancer Cell Line MCF-7 Induces Loss of Estrogen Requirements for Growth and Transformation,Clinical Cancer Research, vol. 1, Nov. 1995, pp. 1429-1436.
William C. Wallace et al.,Amyloid Precursor Protein Requires the Insulin Signaling Pathway for Neurotrophic Activity,Molecular Brain Research, 1997, vol. 52, pp. 213-227.
Gert Wolf et al.,PTB Domains of IRS-1 and She Have Distinct but Overlapping Binding Specificities,The Journal of Biological Chemistry, Nov. 1995, vol. 270(46), pp. 27407-27410.
Mary K. Nolan et al.,Differential Roles of IRS-1 and SHC Signaling Pathways in Breast Cancer Cells,Int. J. Cancer, 1997, vol. 72, pp. 828-834.

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