Antisense oligonucleotides capable of inhibiting the...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S023100, C536S024100, C536S024500, C435S375000, C435S377000

Reexamination Certificate

active

07417033

ABSTRACT:
A pharmaceutical composition that blocks angiogenesis comprising as active agent at least one substance selected from the group consisting of (i) a nucleic acid molecule of a gene coding for protein IRS-1, a complementary sequence or a fragment thereof and (ii) a molecule which inhibits expression of a nucleic acid molecule according to (i).

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Surmacz et al. Clinical Cancer Research vol. 1:1429-1436, 1995.
Consuelo D'Ambrosio, Susanne R. Keller, Andrea Morrione, Gustav E. Lienhard, Renato Baserga, and Ewa Surmacz, Transforming Potential of the Insulin Receptor Substrate 1, Cell Growth & Differentiation vol. 6, 557-562, May 1995.
William C. Wallace, Candan A. Akar, W.E. Lyons, Hemanta K. Kole, Josephine M. Egan, and Ben Wolozin, Amyloid Precursor Protein Requires the Insulin Signaling Pathway for Neurotrophic Activity, Molecular Brain Research 2 (1997) 213-227.

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