Antisense oligonucleotides against nonstructural proteins NS1 an

Details Antisense oligonucleotides against nonstructural proteins NS1 an Antisense oligonucleotides against nonstructural proteins NS1 an

1997-03-04

1998-11-03

LeGuyader, John L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 4351721, 435375, 536 231, 536 241, 536 243, 514 44, C07H 2102, C07H 2104, C12Q 168

Patent

active

058310690

ABSTRACT:
The present invention provides an oligonucleotide having the nucleotide sequence complementary to the respiratory synctial virus nucleotide sequencenumber 98-116 of the respiratory synctial virus antigenome or nucleotide sequence number 627-645 of the respiratory synctial virus antigenome. Also provided is a composition comprising an oligonucleotide according the present invention and a physiologically acceptable carrier therefore. Also provided are various methods of using these novel oligonucleotides.

REFERENCES:
Branch, A. A Good Antisense is Hard to Find. TIBS vol. 23 :45-50, Feb. 1998.
Jairath, S., et al. Inhibition of Respiratory Syncytial Replication by Antisense Oligodeoxyribonucleotides. Antiviral Research vol. 33:201-213, Feb. 1997.

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