Antisense oligonucleotides against hepatitis B viral replication

Details Antisense oligonucleotides against hepatitis B viral replication Antisense oligonucleotides against hepatitis B viral replication

1994-07-28

1997-07-08

Guzo, David

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, C07H 2104

Patent

active

056462620

ABSTRACT:
Antisense oligonucleotides that hybridize to segments of the preS1, S, C, and .epsilon. regions of the hepatitis B virus (HBV) RNA pregenome inhibit replication of the virus. Pharmaceutical compositions which contain these oligonucleotides as the active ingredients are effective against HBV infection.

REFERENCES:
patent: 5190931 (1993-03-01), Inouye
Korba et al., "Inhibition of Hepatitis B Virus Replication in Vitro by Antisense Oligonucleotides", Seventh International Conf. on Antiviral Research, Feb. 27-Mar. 4, 1994, Abst. #80.
Polloch et al., "An RNA Stem-Loop Structure Directs Hepatitis B Virus Genome RNA Encapsidation", J. Virol., Jun. 1993, vol. 67, pp. 3254-3263.
Knaus et al., "The Encapsidation Signal on the Hepatitis B Virus RNA Pregenome Forms a Stem-Loop Structure That is Critical for its Function", Nucleic Acids Res., 1993, vol. 21, No. 17, pp. 3967-3975.
Stein et al. "Antisense Oligonucleotides as Therapeutic . . . ", Science, 261:1004-12, Aug. 1993.
Korba et al. "Use of a Standardized Cell Structure Assay . . . ", Antiviral Research, 19:55-70, Apr. 1992.
Wu et al. "Specific Inhibition of Hepatitis B Viral Gene . . . ", Jrnl. Biol. Chem., 267(18):12436-439, 1992.
Lampertico et al. "Development and Application of an in Vitro Model . . . ", Hepatology, 13(3):422-26, Sep. 1990.
Goodarzi et al. "Antisense Oligodeoxyribonucleotides Inhibit . . . ", Jrnl. Gnr'l. Virology, 71:3021-25, 1990.
Sells et al. "Replicative Intermediates of Hepatitis B . . . ", Jrnl. Virology, 62(8):2836-44, Aug. 1988.
Stein et al. "Oligodeoxynucleotides as Inhibitors of Gene . . . ", Cancer Research, 48:2659-68, May 1988.
Acs et al. "Hepatitis B Virus Produced by Transfected . . . ", Proc. Nat'l. Acad. Sci. USA, 84:4641-44, Jul. 1987.
Sells et al. "Production of Hepatitis B Virus Particles . . . ", Proc. Nat'l. Acad. Sci. USA, 84:1005-09, Feb. 1987.
Korba et al. "Small Deoxyribonucleotides Are Effective Modulators of HBV Functions in Vitro". Molecular Biology of Hepatitis B Viruses Meeting; 1993. Aug. 1-8, 1993 Meeting.

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