Antisense oligonucleotides against ERBB-2

Details Antisense oligonucleotides against ERBB-2 Antisense oligonucleotides against ERBB-2

1996-11-04

1999-06-08

LeGuyader, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 2431, 435 6, 435 911, 435375, C07H 2104, C12Q 168

Patent

active

059105836

ABSTRACT:
oligonucleotides are useful as antisense oligonucleotides for inhibiting the expression of the ERBB2 tyrosine kinase receptor in a cell, in vitro or in vivo.

REFERENCES:
patent: 5599704 (1997-02-01), Thompson et al.
Vaughn et al., "Antisense DNA downregulation of the ERBB2 oncogene measured by a flow cytometric assay", Proc. Natl. Acad. Sci. USA 92:8338-8342, Aug. 1995.
Mahen et al. Archives of Biochem. & Biophys. 253:214-220, 1987.
Gewirtz et al. PNAS 93:3161-3163 (1996).
Rojanasakul Adv. Arug. Delivery Ruvs. 18(1996) 115-131.

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