Antisense oligonucleotide to inhibit melanoma inhibitory...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S023100, C536S024300, C536S024330, C536S024500

Reexamination Certificate

active

07910563

ABSTRACT:
An antisense oligonucleotide selected from the group ofthe sequence 5′-TTG CAT AAA CCC AAG GAG-3′ (SEQ ID NO: 1) and modifications thereofa fragment having at least 8 nucleotides of the sequence 5′-TTG CAT AAA CCC AAG GAG-3′ (SEQ ID NO: 1) and modifications thereof.

REFERENCES:
patent: WO 99/50411 (1999-10-01), None
patent: WO 99/65928 (1999-12-01), None
patent: WO 01/68122 (2001-09-01), None
patent: WO 01/77384 (2001-10-01), None
patent: WO 2005/014812 (2005-02-01), None
Jachimczak et al. Inhibition of Immunosuppressive Effects of Melanoma-Inhibiting Activity (MIA) by Antisense Techniques. Int. J. Cancer, 2005 vol. 113:88-92.
EPO,European Search Report, EP Application No. 03018285.1-2107, dated Feb. 12, 2004.
Golob et al,Characterization of a Transcription Factor Binding Site, Specifically Activating MIA Transcription in Melanoma, J Invest Ermatol 115:42-47, 2000.
PCT,International Search Report, PCT Application No. PCT/EP2004/008986, mailed on Mar. 29, 2005.
Bogdahn, U. et al. / Autocrine Tumor Cell Growth-Inhibiting Activities . . . / Cancer Research, 1989. 49 (19): 5358-5363.
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